Tag: interview
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Functional and molecular neuroimaging of menopause and hormone replacement therapy
Front Neurosci. 2014 Dec 8;8:388. doi: 10.3389/fnins.2014.00388. eCollection 2014. ABSTRACT The level of gonadal hormones to which the female brain is exposed considerably changes across the menopausal transition, which in turn, is likely to be of great relevance for neurodegenerative diseases and psychiatric disorders. However, the neurobiological consequences of these hormone fluctuations and of hormone…
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Familial risk for major depression is associated with lower striatal 5-HT₄ receptor binding
Int J Neuropsychopharmacol. 2014 Oct 31;18(1):pyu034. doi: 10.1093/ijnp/pyu034. ABSTRACT BACKGROUND: The 5-HT4 receptor provides a novel potential target for antidepressant treatment. No studies exist to elucidate the 5-HT4 receptor’s in vivo distribution in the depressed state or in populations that may display trait markers for major depression disorder (MDD). The aim of this study was…
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The effect of storage conditions on salivary cortisol concentrations using an enzyme immunoassay
Scand J Clin Lab Invest. 2015 Jan;75(1):92-5. doi: 10.3109/00365513.2014.985252. Epub 2014 Dec 16. ABSTRACT Saliva samples are easy to collect and are applicable for home-sampling, e.g. when studying HPA-axis dynamics to characterize diurnal cortisol profiles and the cortisol awakening response. However, the storing and transport conditions might be critical in the home-sampling approach. Here, we…
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Mental distress and personality in women undergoing GnRH agonist versus GnRH antagonist protocols for assisted reproductive technology
Hum Reprod. 2015 Jan;30(1):103-10. doi: 10.1093/humrep/deu294. Epub 2014 Nov 14. ABSTRACT STUDY QUESTION: Do mental distress and mood fluctuations in women undergoing GnRH agonist and GnRH antagonist protocols for assisted reproductive technology (ART) differ depending on protocol and the personality trait, neuroticism? SUMMARY ANSWER: ART treatment did not induce elevated levels of mental distress in…
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BDNF Val66met and 5-HTTLPR polymorphisms predict a human in vivo marker for brain serotonin levels
Hum Brain Mapp. 2015 Jan;36(1):313-23. doi: 10.1002/hbm.22630. Epub 2014 Sep 13. ABSTRACT Brain-derived neurotrophic factor (BDNF) has been implicated in multiple aspects of brain function including regulation of serotonin signaling. The BDNF val66met polymorphism (rs6265) has been linked to aspects of serotonin signaling in humans but its effects are not well understood. To address this,…
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Effects of selective serotonin reuptake inhibition on neural activity related to risky decisions and monetary rewards in healthy males
Neuroimage. 2014 Oct 1;99:434-42. doi: 10.1016/j.neuroimage.2014.05.040. Epub 2014 May 22. ABSTRACT Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine are commonly prescribed antidepressant drugs targeting the dysfunctional serotonin (5-HT) system, yet little is known about the functional effects of prolonged serotonin reuptake inhibition in healthy individuals. Here we used functional MRI (fMRI) to investigate how…
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In abstinent MDMA users the cortisol awakening response is off-set but associated with prefrontal serotonin transporter binding as in non-users
Int J Neuropsychopharmacol. 2014 Aug;17(8):1119-28. doi: 10.1017/S1461145714000066. Epub 2014 Feb 14. ABSTRACT Serotonergic signaling is considered critical for an appropriate adaptation to stress. We have previously observed that in healthy volunteers, prefrontal serotonin transporter (SERT) binding is positively associated with hypothalamic-pituitary-adrenal (HPA)-axis output in terms of the cortisol awakening response (CAR). Here, we tested (1)…
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Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer’s disease: a combined [11C]DASB and [18F]altanserin-PET study.
Related Articles Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer’s disease: a combined [11C]DASB and [18F]altanserin-PET study. Neurobiol Aging. 2012 Mar;33(3):479-87 Authors: Marner L, Frokjaer VG, Kalbitzer J, Lehel S, Madsen K, Baaré WF, Knudsen GM, Hasselbalch SG Abstract In patients with Alzheimer’s disease (AD), postmortem and imaging studies have…
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Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer’s disease: a combined [11C]DASB and [18F]altanserin-PET study.
Related Articles Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer’s disease: a combined [11C]DASB and [18F]altanserin-PET study. Neurobiol Aging. 2012 Mar;33(3):479-87 Authors: Marner L, Frokjaer VG, Kalbitzer J, Lehel S, Madsen K, Baaré WF, Knudsen GM, Hasselbalch SG Abstract In patients with Alzheimer’s disease (AD), postmortem and imaging studies have…