Category: My publications

Evaluation of acute tryptophan depletion and sham depletion with a gelatin-based collagen peptide protein mixture. Eur Neuropsychopharmacol. 2015 Nov 26; Authors: Stenbæk DS, Einarsdottir HS, Goregliad-Fjaellingsdal T, Knudsen GM, Frokjaer VG, Hasselbalch SG Abstract Acute Tryptophan Depletion (ATD) is a dietary method used to modulate central 5-HT to study the effects of temporarily reduced 5-HT…

Memory. 2016 Oct;24(9):1208-23. doi: 10.1080/09658211.2015.1087573. Epub 2015 Sep 24. ABSTRACT We here present the development and validation of the Verbal Affective Memory Test-24 (VAMT-24). First, we ensured face validity by selecting 24 words reliably perceived as positive, negative or neutral, respectively, according to healthy Danish adults’ valence ratings of 210 common and non-taboo words. Second,…

Neuropsychopharmacology. 2016 Mar;41(4):1057-65. doi: 10.1038/npp.2015.236. Epub 2015 Aug 6. ABSTRACT Mood disorders are twice as frequent in women than in men. Risk mechanisms for major depression include adverse responses to acute changes in sex-steroid hormone levels, eg, postpartum in women. Such adverse responses may involve an altered processing of rewards. Here, we examine how women’s…

J Neurol Neurosurg Psychiatry. 2016 May;87(5):485-92. doi: 10.1136/jnnp-2015-310958. Epub 2015 Jul 2. ABSTRACT Active, passive and resting state paradigms using functional MRI (fMRI) or EEG may reveal consciousness in the vegetative (VS) and the minimal conscious state (MCS). A meta-analysis was performed to assess the prevalence of preserved consciousness in VS and MCS as revealed…

Biol Psychiatry. 2015 Oct 15;78(8):534-43. doi: 10.1016/j.biopsych.2015.04.015. Epub 2015 Apr 27. ABSTRACT BACKGROUND: An adverse response to acute and pronounced changes in sex-hormone levels during, for example, the perimenopausal or postpartum period appears to heighten risk for major depression in women. The underlying risk mechanisms remain elusive but may include transiently compromised serotonergic brain signaling.…

Neuroimage. 2015 Aug 1;116:187-95. doi: 10.1016/j.neuroimage.2015.04.065. Epub 2015 May 9. ABSTRACT Serotonin (5-HT) is a neurotransmitter critically involved in a broad range of brain functions and implicated in the pathophysiology of neuropsychiatric illnesses including major depression, anxiety and sleep disorders. Despite being widely distributed throughout the brain, there is limited knowledge on the contribution of…

Related Articles Fluctuations in [¹¹C]SB207145 PET binding associated with change in threat-related amygdala reactivity in humans. Neuropsychopharmacology. 2015 May;40(6):1510-8 Authors: Fisher PM, Haahr ME, Jensen CG, Frokjaer VG, Siebner HR, Knudsen GM Abstract Serotonin critically affects the neural processing of emotionally salient stimuli, including indices of threat; however, how alterations in serotonin signaling contribute to…

Related Articles Role of emotional processing in depressive responses to sex-hormone manipulation: a pharmacological fMRI study. Transl Psychiatry. 2015;5:e688 Authors: Henningsson S, Madsen KH, Pinborg A, Heede M, Knudsen GM, Siebner HR, Frokjaer VG Abstract Sex-hormone fluctuations may increase risk for developing depressive symptoms and alter emotional processing as supported by observations in menopausal and…