Category: My publications

Related Articles Neuroticism modulates mood responses to pharmacological sex hormone manipulation in healthy women. Psychoneuroendocrinology. 2018 Oct 26;99:251-256 Authors: Stenbæk DS, Budtz-Jørgensen E, Pinborg A, Jensen PS, Frokjaer VG Abstract BACKGROUND: Women show increased risk of depressive symptoms during hormonal transition phases. The risk mechanisms may include changes in mood in response to fluctuating ovarian…

Acta Anaesthesiol Scand. 2019 Mar;63(3):352-359. doi: 10.1111/aas.13270. Epub 2018 Oct 16. ABSTRACT BACKGROUND: Delirium is underinvestigated in the neuro-critically ill, although the harmful effect of delirium is well established in patients in medical and surgical intensive care units (ICU).To detect delirium, a valid tool is needed. We hypothesized that delirium screening would be feasible in…

Related Articles Delirium assessment in neuro-critically ill patients: A validation study. Acta Anaesthesiol Scand. 2018 Oct 16;: Authors: Larsen LK, Frøkjaer VG, Nielsen JS, Skrobik Y, Winkler Y, Møller K, Petersen M, Egerod I Abstract BACKGROUND: Delirium is underinvestigated in the neuro-critically ill, although the harmful effect of delirium is well established in patients in…

Eur Neuropsychopharmacol. 2018 Oct;28(10):1151-1160. doi: 10.1016/j.euroneuro.2018.06.004. Epub 2018 Aug 1. ABSTRACT We have recently shown that the emergence and severity of seasonal affective disorder (SAD) symptoms in the winter is associated with an increase in cerebral serotonin (5-HT) transporter (SERT) binding. Intriguingly, we also found that individuals resilient to SAD downregulate their cerebral SERT binding…

Related Articles Seasonality-resilient individuals downregulate their cerebral 5-HT transporter binding in winter – A longitudinal combined 11C-DASB and 11C-SB207145 PET study. Eur Neuropsychopharmacol. 2018 Aug 01;: Authors: Mc Mahon B, Nørgaard M, Svarer C, Andersen SB, Madsen MK, Baaré WFC, Madsen J, Frokjaer VG, Knudsen GM Abstract We have recently shown that the emergence and…

Psychoneuroendocrinology. 2018 Mar;89:223-228. doi: 10.1016/j.psyneuen.2017.10.021. Epub 2017 Oct 31. ABSTRACT Perinatal depression (PND) affects 15% of women. During the perinatal period both stress- and gonadal hormones fluctuate widely. Putatively, these fluctuations are involved in PND disease mechanisms. The serotonin system is sensitive to such hormone fluctuations, and serotonin reuptake inhibitors (SSRIs) are used to treat…

Related Articles Paroxetine blunts the corticosterone response to swim-induced stress and increases depressive-like behavior in a rat model of postpartum depression. Psychoneuroendocrinology. 2017 Oct 31;: Authors: Overgaard A, Lieblich SE, Richardson R, Galea LAM, Frokjaer VG Abstract Perinatal depression (PND) affects 15% of women. During the perinatal period both stress- and gonadal hormones fluctuate widely.…

Int J Neuropsychopharmacol. 2017 Dec 1;20(12):963-970. doi: 10.1093/ijnp/pyx071. ABSTRACT BACKGROUND: Neuroticism is a major risk factor for affective disorders. This personality trait has been hypothesized to associate with synaptic availability of the serotonin transporter, which critically controls serotonergic tone in the brain. However, earlier studies linking neuroticism and serotonin transporter have failed to produce converging…

PLoS One. 2017 Sep 7;12(9):e0184403. doi: 10.1371/journal.pone.0184403. eCollection 2017. ABSTRACT Serotonin (5-HT) brain architecture appears to be implicated in normal personality traits as supported by genetic associations and studies using molecular brain imaging. However, so far, no studies have addressed potential contributions to variation in normal personality traits from in vivo serotonin 4 receptor (5-HT4R)…

Related Articles No evidence for a role of the serotonin 4 receptor in five-factor personality traits: A positron emission tomography brain study. PLoS One. 2017;12(9):e0184403 Authors: Stenbæk DS, Dam VH, Fisher PM, Hansen N, Hjordt LV, Frokjaer VG Abstract Serotonin (5-HT) brain architecture appears to be implicated in normal personality traits as supported by genetic…