Category: My publications
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Effects of selective serotonin reuptake inhibition on neural activity related to risky decisions and monetary rewards in healthy males
Neuroimage. 2014 Oct 1;99:434-42. doi: 10.1016/j.neuroimage.2014.05.040. Epub 2014 May 22. ABSTRACT Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine are commonly prescribed antidepressant drugs targeting the dysfunctional serotonin (5-HT) system, yet little is known about the functional effects of prolonged serotonin reuptake inhibition in healthy individuals. Here we used functional MRI (fMRI) to investigate how…
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Does Harm Avoidance mediate effects of recollected parental bonding on mental distress in adulthood?
Related Articles Does Harm Avoidance mediate effects of recollected parental bonding on mental distress in adulthood? Compr Psychiatry. 2014 May;55(4):1007-14 Authors: Stenbæk DS, Jensen CG, Holst KK, Mortensen EL, Knudsen GM, Frokjaer VG Abstract BACKGROUND: Adverse early life conditions such as perceived low quality of parental bonding increase vulnerability to stress and psychopathology in adulthood.…
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Central 5-HT4 receptor binding as biomarker of serotonergic tonus in humans: a [11C]SB207145 PET study.
Related Articles Central 5-HT4 receptor binding as biomarker of serotonergic tonus in humans: a [11C]SB207145 PET study. Mol Psychiatry. 2014 Apr;19(4):427-32 Authors: Haahr ME, Fisher PM, Jensen CG, Frokjaer VG, Mahon BM, Madsen K, Baaré WF, Lehel S, Norremolle A, Rabiner EA, Knudsen GM Abstract Identification of a biomarker that can inform on extracellular serotonin…
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In abstinent MDMA users the cortisol awakening response is off-set but associated with prefrontal serotonin transporter binding as in non-users
Int J Neuropsychopharmacol. 2014 Aug;17(8):1119-28. doi: 10.1017/S1461145714000066. Epub 2014 Feb 14. ABSTRACT Serotonergic signaling is considered critical for an appropriate adaptation to stress. We have previously observed that in healthy volunteers, prefrontal serotonin transporter (SERT) binding is positively associated with hypothalamic-pituitary-adrenal (HPA)-axis output in terms of the cortisol awakening response (CAR). Here, we tested (1)…
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Trait aggression and trait impulsivity are not related to frontal cortex 5-HT2A receptor binding in healthy individuals.
Related Articles Trait aggression and trait impulsivity are not related to frontal cortex 5-HT2A receptor binding in healthy individuals. Psychiatry Res. 2013 May 30;212(2):125-31 Authors: da Cunha-Bang S, Stenbæk DS, Holst K, Licht CL, Jensen PS, Frokjaer VG, Mortensen EL, Knudsen GM Abstract Numerous studies indicate that the serotonergic (5-HT) transmitter system is involved in…
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Prefrontal serotonin transporter availability is positively associated with the cortisol awakening response.
Related Articles Prefrontal serotonin transporter availability is positively associated with the cortisol awakening response. Eur Neuropsychopharmacol. 2013 Apr;23(4):285-94 Authors: Frokjaer VG, Erritzoe D, Holst KK, Jensen PS, Rasmussen PM, Fisher PM, Baaré W, Madsen KS, Madsen J, Svarer C, Knudsen GM Abstract UNLABELLED: Stress sensitivity and serotonergic neurotransmission interact, e.g. individuals carrying the low-expressing variants…
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Hypothalamic-pituitary-adrenal axis tonus is associated with hippocampal microstructural asymmetry.
Related Articles Hypothalamic-pituitary-adrenal axis tonus is associated with hippocampal microstructural asymmetry. Neuroimage. 2012 Oct 15;63(1):95-103 Authors: Madsen KS, Jernigan TL, Iversen P, Frokjaer VG, Knudsen GM, Siebner HR, Baaré WF Abstract It is well-established that prolonged high levels of cortisol have adverse effects on hippocampal neurons and glial cells. Morphometric studies linking hippocampus volume to…
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Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer’s disease: a combined [11C]DASB and [18F]altanserin-PET study.
Related Articles Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer’s disease: a combined [11C]DASB and [18F]altanserin-PET study. Neurobiol Aging. 2012 Mar;33(3):479-87 Authors: Marner L, Frokjaer VG, Kalbitzer J, Lehel S, Madsen K, Baaré WF, Knudsen GM, Hasselbalch SG Abstract In patients with Alzheimer’s disease (AD), postmortem and imaging studies have…
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Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer’s disease: a combined [11C]DASB and [18F]altanserin-PET study.
Related Articles Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer’s disease: a combined [11C]DASB and [18F]altanserin-PET study. Neurobiol Aging. 2012 Mar;33(3):479-87 Authors: Marner L, Frokjaer VG, Kalbitzer J, Lehel S, Madsen K, Baaré WF, Knudsen GM, Hasselbalch SG Abstract In patients with Alzheimer’s disease (AD), postmortem and imaging studies have…
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Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer’s disease: a combined [11C]DASB and [18F]altanserin-PET study.
Related Articles Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer’s disease: a combined [11C]DASB and [18F]altanserin-PET study. Neurobiol Aging. 2012 Mar;33(3):479-87 Authors: Marner L, Frokjaer VG, Kalbitzer J, Lehel S, Madsen K, Baaré WF, Knudsen GM, Hasselbalch SG Abstract In patients with Alzheimer’s disease (AD), postmortem and imaging studies have…