Sticky Watch the replay of my lecture: “Female sex hormones, brain function, and mental health: how sex hormones shape our brain” @ Science & Cocktails event July 4, 2021, DR Koncerthuset Copenhagen

by Vibe

July 4, 2021, DR Koncerthuset Copenhagen →Read more

Brain serotonin transporter is associated with cognitive-affective biases in healthy individuals

by Sophia Armand

Hum Brain Mapp. 2022 May 24. doi: 10.1002/hbm.25946. Online ahead of print. ABSTRACT Cognitive affective biases describe the tendency to process negative information or positive information over the other. These biases can be modulated by changing extracellular serotonin (5-HT) levels in the brain, for example, by pharmacologically blocking and downregulating the 5-HT transporter (5-HTT), which […]? →Read more

Systemic DNA and RNA damage from oxidation after serotonergic treatment of unipolar depression

by Anders Jorgensen

Transl Psychiatry. 2022 May 16;12(1):204. doi: 10.1038/s41398-022-01969-z. ABSTRACT Previous studies have indicated that antidepressants that inhibit the serotonin transporter reduces oxidative stress. DNA and RNA damage from oxidation is involved in aging and a range of age-related pathophysiological processes. Here, we studied the urinary excretion of markers of DNA and RNA damage from oxidation, 8-oxodG […]? →Read more

Emotional faces processing in major depressive disorder and prediction of antidepressant treatment response: A NeuroPharm study

by Patrick M Fisher

J Psychopharmacol. 2022 May 13:2698811221089035. doi: 10.1177/02698811221089035. Online ahead of print. ABSTRACT BACKGROUND: Major depressive disorder (MDD) is a prevalent neuropsychiatric illness for which it is important to resolve underlying brain mechanisms. Current treatments are often unsuccessful, precipitating a need to identify predictive markers. AIM: We evaluated (1) alterations in brain responses to an emotional […]? →Read more

Family history of psychiatric disorders as a risk factor for maternal postpartum depression: a systematic review protocol

by Mette-Marie Zacher Kjeldsen

Syst Rev. 2022 Apr 15;11(1):68. doi: 10.1186/s13643-022-01952-1. ABSTRACT BACKGROUND: Postpartum depression (PPD) is the most common postpartum psychiatric disorder, affecting 11-15% of new mothers, and initiatives towards early identification and treatment are essential due to detrimental consequences. Family history of psychiatric disorders is a risk factor for developing psychiatric episodes outside the postpartum period, but […]? →Read more

The Impact of Hormonal Contraceptive Use on Serotonergic Neurotransmission and Antidepressant Treatment Response: Results From the NeuroPharm 1 Study

by S ren Vinther Larsen

Front Endocrinol (Lausanne). 2022 Mar 11;13:799675. doi: 10.3389/fendo.2022.799675. eCollection 2022. ABSTRACT BACKGROUND: Hormonal contraceptive (HC) use has been associated with an increased risk of developing a depressive episode. This might be related to HC’s effect on the serotonergic brain system as suggested by recent cross-sectional data from our group, which show that healthy oral contraceptive […]? →Read more

Stress-Hormone Dynamics and Working Memory in Healthy Women Who Use Oral Contraceptives <em>Versus</em> Non-Users

by Emma Sofie H gsted

Front Endocrinol (Lausanne). 2021 Nov 8;12:731994. doi: 10.3389/fendo.2021.731994. eCollection 2021. ABSTRACT BACKGROUND: Women who use oral contraceptives (OCs) may have a higher risk of developing a depression, which is associated with both vulnerability to stress and cognitive dysfunction. OCs disrupt the hypothalamic-pituitary-gonadal (HPG) axis by suppressing endogenous sex steroid production including estradiol. The HPG axis […]? →Read more

Stress-Hormone Dynamics and Working Memory in Healthy Women Who Use Oral Contraceptives Versus Non-Users

by Emma Sofie Høgsted

Front Endocrinol (Lausanne). 2021 Nov 8;12:731994. doi: 10.3389/fendo.2021.731994. eCollection 2021. ABSTRACT BACKGROUND: Women who use oral contraceptives (OCs) may have a higher risk of developing a depression, which is associated with both vulnerability to stress and cognitive dysfunction. OCs disrupt the hypothalamic-pituitary-gonadal (HPG) axis by suppressing endogenous sex steroid production including estradiol. The HPG axis […]? →Read more

NeuroPharm study: EEG wakefulness regulation as a biomarker in MDD

by Cheng-Teng Ip

J Psychiatr Res. 2021 Jun 18;141:57-65. doi: 10.1016/j.jpsychires.2021.06.021. Online ahead of print. ABSTRACT While several electroencephalogram (EEG)-based biomarkers have been proposed as diagnostic or predictive tools in major depressive disorder (MDD), there is a clear lack of replication studies in this field. Markers that link clinical features such as disturbed wakefulness regulation in MDD with […]? →Read more

Brain reactivity during aggressive response in women with premenstrual dysphoric disorder treated with a selective progesterone receptor modulator

by Elisavet Kaltsouni

Neuropsychopharmacology. 2021 Apr 29. doi: 10.1038/s41386-021-01010-9. Online ahead of print. ABSTRACT Premenstrual dysphoric disorder (PMDD) is a psychiatric condition characterized by late luteal phase affective, cognitive, and physical impairment. The disorder causes significant suffering in about 5% of women in their reproductive age. Altered sensitivity of cognitive-affective brain circuits to progesterone and its downstream metabolite […]? →Read more