NeuroPharm study: EEG wakefulness regulation as a biomarker in MDD

J Psychiatr Res. 2021 Jun 18;141:57-65. doi: 10.1016/j.jpsychires.2021.06.021. Online ahead of print. ABSTRACT While several electroencephalogram (EEG)-based biomarkers have been proposed as diagnostic or predictive tools in major depressive disorder (MDD), there is a clear lack of replication studies in this field. Markers that link clinical features such as disturbed wakefulness regulation in MDD with […]? →Read more

Brain reactivity during aggressive response in women with premenstrual dysphoric disorder treated with a selective progesterone receptor modulator

Neuropsychopharmacology. 2021 Apr 29. doi: 10.1038/s41386-021-01010-9. Online ahead of print. ABSTRACT Premenstrual dysphoric disorder (PMDD) is a psychiatric condition characterized by late luteal phase affective, cognitive, and physical impairment. The disorder causes significant suffering in about 5% of women in their reproductive age. Altered sensitivity of cognitive-affective brain circuits to progesterone and its downstream metabolite […]? →Read more

Pretreatment qEEG biomarkers for predicting pharmacological treatment outcome in major depressive disorder: Independent validation from the NeuroPharm study

Eur Neuropsychopharmacol. 2021 Apr 25;49:101-112. doi: 10.1016/j.euroneuro.2021.03.024. Online ahead of print. ABSTRACT Several electroencephalogram (EEG) biomarkers for prediction of drug response in major depressive disorder (MDD) have been proposed, but validations in larger independent datasets are missing. In the current study, we investigated the prognostic value of previously suggested EEG biomarkers. We gathered data that […]? →Read more

Default Mode Network Functional Connectivity Negatively Associated with Trait Openness to Experience

Soc Cogn Affect Neurosci. 2021 Apr 23:nsab048. doi: 10.1093/scan/nsab048. Online ahead of print. ABSTRACT Evaluating associations between the five-factor personality domains and resting-state functional connectivity networks (e.g., default mode network, DMN) highlights distributed neurobiological systems linked to behaviorally relevant phenotypes. Establishing these associations can highlight a potential underlying role for these neural pathways in related […]? →Read more

Genome-wide gene expression changes in postpartum depression point towards an altered immune landscape

Transl Psychiatry. 2021 Mar 4;11(1):155. doi: 10.1038/s41398-021-01270-5. ABSTRACT Maternal postpartum depression (PPD) is a significant public health concern due to the severe negative impact on maternal and child health and well-being. In this study, we aimed to identify genes associated with PPD. To do this, we investigated genome-wide gene expression profiles of pregnant women during […]? →Read more

Associations between the cortisol awakening response and patient-evaluated stress and mood instability in patients with bipolar disorder: an exploratory study

Int J Bipolar Disord. 2021 Mar 1;9(1):8. doi: 10.1186/s40345-020-00214-0. ABSTRACT OBJECTIVE: The Cortisol Awakening Response (CAR) measured as the transient increase in cortisol levels following morning awakening appears to be a distinct feature of the HPA axis. Patients with bipolar disorder (BD) experience daily stress, mood instability (MI) and studies have shown disrupted HPA-axis dynamics. […]? →Read more

Reward processing in major depressive disorder and prediction of treatment response – Neuropharm study

Eur Neuropsychopharmacol. 2021 Mar;44:23-33. doi: 10.1016/j.euroneuro.2020.12.010. Epub 2021 Jan 15. ABSTRACT Major depressive disorder (MDD) is a prevalent brain disorder for which anhedonia is a core symptom, indicating aberrations in the neural processing of reward. The striatum, medial prefrontal cortex (mPFC) and anterior insula (AI) are core reward processing regions. Here we used a reward-related, […]? →Read more

Reward processing in major depressive disorder and prediction of treatment response – Neuropharm study.

Related Articles Reward processing in major depressive disorder and prediction of treatment response – Neuropharm study. Eur Neuropsychopharmacol. 2021 Jan 14;: Authors: Brandt IM, Köhler-Forsberg K, Ganz M, Ozenne B, Jorgensen MB, Poulsen A, Knudsen GM, Frokjaer VG, Fisher PM Abstract Major depressive disorder (MDD) is a prevalent brain disorder for which anhedonia is a […]? →Read more

Oral contraceptives and the serotonin 4 receptor: a molecular brain imaging study in healthy women

Acta Psychiatr Scand. 2020 Oct;142(4):294-306. doi: 10.1111/acps.13211. Epub 2020 Jul 21. ABSTRACT OBJECTIVE: Sex steroid hormones potently shape brain functions, including those critical to maintain mental health such as serotonin signaling. Use of oral contraceptives (OCs) profoundly changes endogenous sex steroid hormone levels and dynamics. Recent register-based studies show that starting an OC is associated […]? →Read more

Cognitive processing of infant stimuli in pregnant women with and without affective disorders and the association to postpartum depression

Eur Neuropsychopharmacol. 2021 Jan;42:97-109. doi: 10.1016/j.euroneuro.2020.10.006. Epub 2020 Nov 3. ABSTRACT Pregnancy and childbirth are among the strongest risk factors for depression but the neurocognitive mechanisms underlying this enhanced risk are unknown. This study investigated emotional and non-emotional cognition in 57 pregnant women with or without an affective disorder during their third trimester, and the […]? →Read more