{"id":378,"date":"2021-06-27T10:00:00","date_gmt":"2021-06-27T10:00:00","guid":{"rendered":"http:\/\/www.vibegf.dk\/wp\/378\/neuropharm-study-eeg-wakefulness-regulation-as-a-biomarker-in-mdd"},"modified":"2021-06-27T10:00:00","modified_gmt":"2021-06-27T10:00:00","slug":"neuropharm-study-eeg-wakefulness-regulation-as-a-biomarker-in-mdd","status":"publish","type":"post","link":"https:\/\/www.vibegf.dk\/wp\/378\/neuropharm-study-eeg-wakefulness-regulation-as-a-biomarker-in-mdd","title":{"rendered":"NeuroPharm study: EEG wakefulness regulation as a biomarker in MDD"},"content":{"rendered":"<div>\n<p style=\"color: #4aa564\">J Psychiatr Res. 2021 Jun 18;141:57-65. doi: 10.1016\/j.jpsychires.2021.06.021. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>While several electroencephalogram (EEG)-based biomarkers have been proposed as diagnostic or predictive tools in major depressive disorder (MDD), there is a clear lack of replication studies in this field. Markers that link clinical features such as disturbed wakefulness regulation in MDD with neurophysiological patterns are particularly promising candidates for e.g., EEG-informed choices of antidepressive treatment. We investigate if we in an independent MDD sample can replicate abnormal findings of EEG-vigilance regulation during rest and as a predictor for antidepressive treatment response. EEG-resting state was recorded in 91 patients and 35 healthy controls from the NeuroPharm trial. EEG-vigilance was assessed using the Vigilance Algorithm Leipzig (VIGALL). We compared the vigilance regulation during rest between patients and healthy controls and between remitters\/responders and non-remitters\/non-responders after eight weeks of SSRI\/SNRI treatment using two different sets of response criteria (NeuroPharm and iSPOT-D). We replicated previous findings showing hyperstable EEG-wakefulness regulation in patients in comparison to healthy subjects. Responders defined by the iSPOT-D criteria showed a higher propensity toward low vigilance stages in comparison to patients with no response at pretreatment, however, this did not apply when using the NeuroPharm criteria. EEG-wakefulness regulation patterns normalized toward patterns of healthy controls after 8 weeks of treatment. This replication study supports the diagnostic value of EEG-vigilance regulation and its usefulness as a biomarker for the choice of treatment in MDD.<\/p>\n<p style=\"color: lightgray\">PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34175743\/?utm_source=Other&amp;utm_medium=rss&amp;utm_content=1BqdMZQc79a-OkXf_YXqXC3bQ8vqAJkzOWChNgA85Z0GL85cH8&amp;ff=20210629200217&amp;v=2.14.4\">34175743<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.jpsychires.2021.06.021\">10.1016\/j.jpsychires.2021.06.021<\/a><\/p>\n<\/div>\n<p>Source: My publications feed from NCBI<\/p>\n","protected":false},"excerpt":{"rendered":"<p>J Psychiatr Res. 2021 Jun 18;141:57-65. doi: 10.1016\/j.jpsychires.2021.06.021. Online ahead of print. ABSTRACT While several electroencephalogram (EEG)-based biomarkers have been proposed as diagnostic or predictive tools in major depressive disorder (MDD), there is a clear lack of replication studies in this field. Markers that link clinical features such as disturbed wakefulness regulation in MDD with [&hellip;]<\/p>\n","protected":false},"author":43,"featured_media":0,"comment_status":"false","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[7],"class_list":["post-378","post","type-post","status-publish","format-standard","hentry","category-mypublications","tag-interview"],"_links":{"self":[{"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/posts\/378","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/users\/43"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/comments?post=378"}],"version-history":[{"count":0,"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/posts\/378\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/media?parent=378"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/categories?post=378"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/tags?post=378"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}