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\nA PET [18F]altanserin study of 5-HT2A receptor binding in the human brain and responses to painful heat stimulation.
\nNeuroimage. 2009 Feb 1;44(3):1001-7
\nAuthors: Kupers R, Frokjaer VG, Naert A, Christensen R, Budtz-Joergensen E, Kehlet H, Knudsen GM
\nAbstract
\nThere is a large body of evidence that serotonin [5-hydroxytryptamine (5-HT)] plays an important role in the transmission and regulation of pain. Here we used positron emission tomography (PET) to study the relationship between baseline 5-HT(2A) binding in the brain and responses to noxious heat stimulation in a group of young healthy volunteers. Twenty-one healthy subjects underwent PET scanning with the 5-HT(2A) antagonist, [(18)F]altanserin. In addition, participants underwent a battery of pain tests using noxious heat stimulation to assess pain threshold, pain tolerance and response to short-lasting phasic and long-lasting (7-minute) tonic painful stimulation. Significant positive correlations were found between tonic pain ratings and [(18)F]altanserin binding in orbitofrontal (r=0.66; p=0.005), medial inferior frontal (r=0.60; p=0.014), primary sensory-motor (r=0.61; p=0.012) and posterior cingulate (r=0.63; p=0.009) cortices. In contrast, measures of regional [(18)F]altanserin binding did not correlate with pain threshold, pain tolerance, or suprathreshold phasic pain responses. These data suggest that cortical 5-HT(2A) receptor availability co-varies with responses to tonic pain. The correlation between [(18)F]altanserin binding in prefrontal cortex and tonic pain suggests a possible role of this brain region in the modulation and\/or cognitive-evaluative appreciation of pain.
\nPMID: 19007894 [PubMed – indexed for MEDLINE]
\nSource: My publications feed from NCBI<\/p>\n","protected":false},"excerpt":{"rendered":"
Related Articles A PET [18F]altanserin study of 5-HT2A receptor binding in the human brain and responses to painful heat stimulation. Neuroimage. 2009 Feb 1;44(3):1001-7 Authors: Kupers R, Frokjaer VG, Naert A, Christensen R, Budtz-Joergensen E, Kehlet H, Knudsen GM Abstract There is a large body of evidence that serotonin [5-hydroxytryptamine (5-HT)] plays an important role […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-36","post","type-post","status-publish","format-standard","hentry","category-mypublications"],"_links":{"self":[{"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/posts\/36","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/comments?post=36"}],"version-history":[{"count":1,"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/posts\/36\/revisions"}],"predecessor-version":[{"id":87,"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/posts\/36\/revisions\/87"}],"wp:attachment":[{"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/media?parent=36"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/categories?post=36"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/tags?post=36"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}