{"id":241,"date":"2019-02-28T00:01:00","date_gmt":"2019-02-28T00:01:00","guid":{"rendered":"http:\/\/www.vibegf.dk\/wp\/241\/recreational-use-of-psychedelics-is-associated-with-elevated-personality-trait-openness-exploration-of-associations-with-brain-serotonin-markers"},"modified":"2019-05-06T19:00:20","modified_gmt":"2019-05-06T19:00:20","slug":"recreational-use-of-psychedelics-is-associated-with-elevated-personality-trait-openness-exploration-of-associations-with-brain-serotonin-markers","status":"publish","type":"post","link":"https:\/\/www.vibegf.dk\/wp\/241\/recreational-use-of-psychedelics-is-associated-with-elevated-personality-trait-openness-exploration-of-associations-with-brain-serotonin-markers","title":{"rendered":"Recreational use of psychedelics is associated with elevated personality trait openness: Exploration of associations with brain serotonin markers."},"content":{"rendered":"\n\n\n
\"Icon<\/a><\/td>\nRelated Articles<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Recreational use of psychedelics is associated with elevated personality trait openness: Exploration of associations with brain serotonin markers.<\/b><\/p>\n

J Psychopharmacol. 2019 Feb 28;:269881119827891<\/p>\n

Authors: Erritzoe D, Smith J, Fisher PM, Carhart-Harris R, Frokjaer VG, Knudsen GM<\/p>\n

Abstract
\nBACKGROUND:: Recent studies have suggested therapeutic benefits of psychedelics for a variety of mental health conditions. The understanding of how single psychedelic administrations can induce long-lasting effects are, in large, still lacking. However, recent studies in both healthy and clinical populations suggest a role for personality changes.
\nAIM:: To test support for some of these plausible mechanisms we evaluated (cross-sectional) associations between recreational use of psychedelics and 3,4-methylene-dioxymethamphetamine (MDMA) and (a) personality measures and (b) key markers of cerebral serotonergic signalling (serotonin transporter and serotonin-2A-receptor binding).
\nMETHODS:: In 10 psychedelic-preferring recreational users, 14 MDMA-preferring users and 21 non-using controls, personality was assessed using the ‘big five’ instrument Revised NEO Personality Inventory (NEO-PI-R). Frontal serotonin transporter and serotonin-2A-receptor binding potentials were quantified using [11C]DASB and [18F]altanserin positron emission tomography, respectively.
\nRESULTS:: Of the five NEO-PI-R traits, only openness to experience scores differed between the three groups; psychedelic-preferring recreational users showing higher openness to experience scores when compared with both MDMA-preferring users and controls. Openness to experience scores were positively associated with lifetime number of psychedelic exposures, and among all MDMA-preferring user\/psychedelic-preferring recreational user individuals, frontal serotonin transporter binding – but not frontal serotonin-2A-receptor binding – was positively associated with openness to experience.
\nCONCLUSION:: Our findings from this cross-sectional study support increasing evidence of a positive association between psychedelic experiences and openness to experience, and (a) expands this to the context of ‘recreational’ psychedelics use, and (b) links serotonergic neurotransmission to openness to experience. A modulation of personality induced by psychedelic experiences may have important therapeutic implications via its impact on peoples’ value systems, cognitive flexibility, and individual and social behaviour.<\/p>\n

PMID: 30816797 [PubMed – as supplied by publisher]<\/p>\n

Source: My publications feed from NCBI<\/p>\n","protected":false},"excerpt":{"rendered":"

Related Articles Recreational use of psychedelics is associated with elevated personality trait openness: Exploration of associations with brain serotonin markers. J Psychopharmacol. 2019 Feb 28;:269881119827891 Authors: Erritzoe D, Smith J, Fisher PM, Carhart-Harris R, Frokjaer VG, Knudsen GM Abstract BACKGROUND:: Recent studies have suggested therapeutic benefits of psychedelics for a variety of mental health conditions. […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[7],"class_list":["post-241","post","type-post","status-publish","format-standard","hentry","category-mypublications","tag-interview"],"_links":{"self":[{"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/posts\/241","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/comments?post=241"}],"version-history":[{"count":1,"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/posts\/241\/revisions"}],"predecessor-version":[{"id":244,"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/posts\/241\/revisions\/244"}],"wp:attachment":[{"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/media?parent=241"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/categories?post=241"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vibegf.dk\/wp\/wp-json\/wp\/v2\/tags?post=241"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}