Podcast interview from Weekendavisen about estrogen and the brain – in Danish

  Østrogen og skarpe hjerner   Listen her: Source: https://www.weekendavisen.dk/2020-39/24spoergsmaal/oestrogen-og-skarpe-hjerner →Read more

Oral contraceptives and the serotonin 4 receptor: a molecular brain imaging study in healthy women.

Related Articles Oral contraceptives and the serotonin 4 receptor: a molecular brain imaging study in healthy women. Acta Psychiatr Scand. 2020 Oct;142(4):294-306 Authors: Larsen SV, Köhler-Forsberg K, Dam VH, Poulsen AS, Svarer C, Jensen PS, Knudsen GM, Fisher PM, Ozenne B, Frokjaer VG Abstract OBJECTIVE: Sex steroid hormones potently shape brain functions, including those critical […]? →Read more

Effect of supervised group exercise on psychological well-being among pregnant women with or at high risk of depression (the EWE Study): A randomized controlled trial

Acta Obstet Gynecol Scand. 2021 Jan;100(1):129-138. doi: 10.1111/aogs.13982. Epub 2020 Sep 15. ABSTRACT INTRODUCTION: Depression is expected to be the leading cause of disability worldwide by 2030. The prevalence is increasing and is two-fold higher in women than in men, women being at particularly high risk during hormonal transition phases such as pregnancy and the […]? →Read more

Effect of supervised group exercise on psychological well-being among pregnant women with or at high risk of depression (the EWE Study): a randomized controlled trial.

Related Articles Effect of supervised group exercise on psychological well-being among pregnant women with or at high risk of depression (the EWE Study): a randomized controlled trial. Acta Obstet Gynecol Scand. 2020 Aug 30;: Authors: Broberg L, Tabor A, Rosthøj S, Backhausen M, Frokjaer VG, Damm P, Hegaard HK Abstract INTRODUCTION: Depression is expected to […]? →Read more

Predicting Treatment Outcome in Major Depressive Disorder Using Serotonin 4 Receptor PET Brain Imaging, Functional MRI, Cognitive-, EEG-Based, and Peripheral Biomarkers: A NeuroPharm Open Label Clinical Trial Protocol.

Related Articles Predicting Treatment Outcome in Major Depressive Disorder Using Serotonin 4 Receptor PET Brain Imaging, Functional MRI, Cognitive-, EEG-Based, and Peripheral Biomarkers: A NeuroPharm Open Label Clinical Trial Protocol. Front Psychiatry. 2020;11:641 Authors: Köhler-Forsberg K, Jorgensen A, Dam VH, Stenbæk DS, Fisher PM, Ip CT, Ganz M, Poulsen HE, Giraldi A, Ozenne B, Jørgensen […]? →Read more

Predicting Treatment Outcome in Major Depressive Disorder Using Serotonin 4 Receptor PET Brain Imaging, Functional MRI, Cognitive-, EEG-Based, and Peripheral Biomarkers: A NeuroPharm Open Label Clinical Trial Protocol

Front Psychiatry. 2020 Jul 23;11:641. doi: 10.3389/fpsyt.2020.00641. eCollection 2020. ABSTRACT BACKGROUND: Between 30 and 50% of patients with major depressive disorder (MDD) do not respond sufficiently to antidepressant regimens. The conventional pharmacological treatments predominantly target serotonergic brain signaling but better tools to predict treatment response and identify relevant subgroups of MDD are needed to support […]? →Read more

Article from Videnskab.dk about my latest Contraceptive pill research

Endnu et studie viser, hvordan p-piller ændrer på kvinders hjernekemi Read more here: https://videnskab.dk/krop-sundhed/endnu-et-studie-viser-hvordan-p-piller-aendrer-paa-kvinders-hjernekemi     →Read more

Grant from Independent Research Fund DK

Hormonal sensitivity and brain function: Do oral contraceptives distort serotonergic brain architecture and does discontinuation restore it? FORSKNINGSPROJEKT 1 SUNDHED OG SYGDOM 2020 link MODTAGER Vibe Gedsø Frøkjær RIGSHOSPITALET BEVILGET BELØB 2.051.690 kr Women who use oral contraceptives face an increased risk of developing depressive episodes. We do not know why. Recent cross-sectional findings from our […]? →Read more

Identification of a Serotonin 2A Receptor Subtype of Schizophrenia Spectrum Disorders With Pimavanserin: The Sub-Sero Proof-of-Concept Trial Protocol

Front Pharmacol. 2020 Apr 30;11:591. doi: 10.3389/fphar.2020.00591. eCollection 2020. ABSTRACT BACKGROUND: All current approved antipsychotic drugs against schizophrenia spectrum disorders share affinity for the dopamine receptor (D2R). However, up to one-third of these patients respond insufficiently, and in some cases, side-effects outweigh symptom reduction. Previous data have suggested that a subgroup of antipsychotic-naïve patients will […]? →Read more

Pharmacological sex hormone manipulation as a risk model for depression

J Neurosci Res. 2020 Jul;98(7):1283-1292. doi: 10.1002/jnr.24632. Epub 2020 May 12. ABSTRACT Sex hormone transition may trigger severe depressive episodes in some women. In order to map mechanisms related to such phenomena we developed a pharmacological preclinical human model using sex hormone manipulation with gonadotropin releasing hormone agonist (GnRHa) in a placebo-controlled design. Here the […]? →Read more