Month: March 2016

  • Seasonal difference in brain serotonin transporter binding predicts symptom severity in patients with seasonal affective disorder

    Brain. 2016 May;139(Pt 5):1605-14. doi: 10.1093/brain/aww043. Epub 2016 Mar 19. ABSTRACT Cross-sectional neuroimaging studies in non-depressed individuals have demonstrated an inverse relationship between daylight minutes and cerebral serotonin transporter; this relationship is modified by serotonin-transporter-linked polymorphic region short allele carrier status. We here present data from the first longitudinal investigation of seasonal serotonin transporter fluctuations […]

  • Sex hormone manipulation slows reaction time and increases labile mood in healthy women

    Psychoneuroendocrinology. 2016 Jun;68:39-46. doi: 10.1016/j.psyneuen.2016.02.023. Epub 2016 Feb 26. ABSTRACT BACKGROUND: Women show increased risk of depressive symptoms in life phases where ovarian steroid hormone levels fluctuate or decline rapidly. The risk mechanisms may include changes in mental state and affective cognition possibly mediated by serotonergic neurotransmission. METHODS: In a randomized controlled double-blinded trial, 61 […]

  • Sex-Steroid Hormone Manipulation Reduces Brain Response to Reward.

    Related Articles Sex-Steroid Hormone Manipulation Reduces Brain Response to Reward. Neuropsychopharmacology. 2015 Aug 6; Authors: Macoveanu J, Henningsson S, Pinborg A, Jensen P, Knudsen GM, Frokjaer VG, Siebner HR Abstract Mood disorders are twice as frequent in women than in men. Risk mechanisms for major depression include adverse responses to acute changes in sex-steroid hormone […]